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In a seminal March 2021 New England Journal of Medicine study, adults receiving a weekly 2.4 mg injection of semaglutide for about 15 months lost 15% of their body weight35 pounds, on averagecompared to just 2.4% body weight loss in the placebo group

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In some embodiments, the otic formulation or composition comprises about 0.5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In some embodiments, the otic pharmaceutical formulation comprises about 97% by weight of the triglycerides

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Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Reduces Neuroinflammation From Stroke via the Activation of Insulin-Like Growth Factor 1 Receptor in Astrocytes